Role of vitamin E in preventing arteriohyalinization in kidneys of streptozotocin induced diabetic mice.

OBJECTIVE To evaluate the role of vitamin E on the arteriolar hyalinisation in kidneys of diabetic mice. METHODS The laboratory-based randomised control trial was conducted at the Department of Anatomy, Army Medical College, Rawalpindi, in collaboration with National Institute of Health, Islamabad, from November 2009 to November 2010. Adult female BALB/C mice were randomly divided into three groups. Group A served as control group. Group B was made diabetic by the intraperitoneal injection of streptozotocin. Group C received streptozotocin injection and was fed with vitamin E (alphatocopherol) supplemented diet. After 12 weeks,the animals were sacrificed and their kidneys were removed for histomorphological study. SPSS 16 was used for statistical analysis. RESULTS Diabetes caused significant histomorphological changes in arteriole of kidneys of Experimental Group B compared to Control Group A (p>0.05), but these changes were prevented in Group C. In experimental group B, 2(20%) animals had arteriolar hyalinisation of score 1, while score 2 was revealed in 8(80%) animals. Experimental group C showed no hyalinisation in any arteriole. CONCLUSIONS Vitamin E prevents the arteriohyalinization in kidneys of mice with STZ induced diabetes.